Chemical Information
Name Labetalol Hydrochloride
Formula CHNOHCl
Molecular Weight 3649 gmol including the HCl salt
Form Usually appears as a white or offwhite crystalline powder
Solubility Soluble in water
Pharmacological Class
Betaadrenergic blocker nonselective and alpha1 adrenergic blocker
Mechanism of Action
Blocks beta1 and beta2 receptors reduces heart rate and cardiac output
Blocks alpha1 receptors causes vasodilation
Combined effect lowers blood pressure without causing reflex tachycardia a typical side effect of pure vasodilators
Uses
Primary Indication Treatment of hypertension including hypertensive emergencies
Also used in pregnancyinduced hypertension preeclampsia
Routes of Administration
Oral tablets
Intravenous injection for acute settings
Side Effects
Dizziness
Fatigue
Nausea
Orthostatic hypotension
Bradycardia
Contraindications
Bronchial asthma
Overt cardiac failure
Heart block greater than first degree
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AMBICA CHEMICALS
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